Dementia
Conditions
Interventions
Control group:12-week observation, followed by 12-week vibration intervention
Experimental group:12-week vibration intervention, followed by 12-week observation
Sponsors
Health and Medical Research Fund
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: Community-living Chinese individuals aged 60 or older with sarcopenia but without clinical dementia will be recruited from local elderly centres equipped with our vibration platform, V-Health. All individuals will be screened at our research centre (the Orthopaedic Learning Centre) for the following: 1. presence of sarcopenia, defined according to the latest diagnostic criteria published by the Asian Working Group of Sarcopenia (AWGS): (1) hand-grip strength (male at < 28kg; female at < 18kg), (2) 6-metre gait speed test (< 1.0m/s), and (3) height-adjusted skeletal muscle mass measured by dual-energy X-ray absorptiometry (DXA, male at <7.0kg/m2 and female at < 5.4kg/m2), defined by appendicular skeletal muscle mass/height2 2. at risk of dementia, according to age- and education-matched cutoff of the Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA); 3. being able to stand independently without any aids; and 4. not receiving vibration treatment in the past 1 year.
Exclusion criteria
Exclusion criteria: Exclusion criteria include non-Chinese ethnicity; living in care homes; having history of dementia, stroke, traumatic brain injury, epilepsy, or Parkinsons disease; taking drugs that affect cognition (benzodiazepines, anti-dementia medication, etc.); having history of severe mental illness (SMI), including bipolar affective disorder and schizophrenia, or substance abuse; already attending other cognitive intervention programs; significant impairments in communication; having any hormonal replacement therapy or drug treatment that could affect normal metabolism of musculoskeletal system; having any hypo- or hyperparathyroidism, renal, liver, or chronic inflammatory conditions known to affect muscle metabolism; having pacemaker or implant in situ; having difficulty in standing independently; and already having regular vibration treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive domains;Efficiency of brain network; | — |
Countries
China
Contacts
Public ContactAllen Ting Chun LEE
Chinese University of Hong Kong
Outcome results
None listed