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Effects of ischemic preconditioning on the levels of HIF-1 a, Bcl-2, Bax and Caspase-3 in peripheral blood of patients with recanalization after acute cerebral infarction

Effects of ischemic preconditioning on the levels of HIF-1 a, Bcl-2, Bax and Caspase-3 in peripheral blood of patients with recanalization after acute cerebral infarction

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053907
Enrollment
Unknown
Registered
2021-12-02
Start date
2021-12-15
Completion date
Unknown
Last updated
2022-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute cerebral infarction

Interventions

Experimental group:Ischemic preconditioning was performed

Sponsors

The Second Affiliated Hospital of Shandong First Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 80 years, male or female; 2. Patients diagnosed with AIS who underwent vascular recanalization; 3. The pre-stroke Rankin Scale (mRS) score is less than 0 to 4; 4. National Institutes of Health Stroke Scale (NIHSS) score 2-25 before thrombolysis; 5. Glasgow Coma Scale (GCS) >= 8 points; 6. The patient or his legal representative agrees to the treatment and signs the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications to RIPC, such as severe soft tissue injury, fracture, subclavian steal syndrome or upper extremity peripheral vascular disease; patients with a history of atrial fibrillation or ECG suggestive of atrial fibrillation; 2. Pregnant or lactating women; 3. Unwillingness to follow up or poor treatment compliance; 4. Patients who have participated in or have participated in another clinical trial within 3 months of this clinical trial.

Design outcomes

Primary

MeasureTime frame
Hypoxia-inducible factor-1a;B-lymphoma-2;B-lymphocytoma 2-linked X protein;caspase-3;

Countries

China

Contacts

Public ContactZhang Yanbo

The Second Affiliated Hospital of Shandong First Medical University

bbnnbn@163.com+86 13053872839

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026