Osteoarthritis of knee joint
Conditions
Interventions
Group A:TXA 20mg/kg+100ml normal saline was intravenously instilled 10 minutes before skin incision, and the instillation was completed 10 minutes
Group B:Inject TXA 20mg/kg+100ml saline 10 minutes before loosening the tourniquet, and finish the instillation within 10 minutes
Sponsors
Panzhihua Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for severe knee osteoarthritis of the American College of Rheumatology; 2. Patients who are ineffective after strict conservative treatment; 3. First time receiving unilateral TKA surgery; 4. The patients and their families agreed to the operation, were informed about the research and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who have anemia or other blood system diseases before surgery; 2. Patients with a history of severe cardiovascular disease and/or still taking oral anticoagulant drugs before surgery; 3. Patients with prior arterial occlusion, venous thrombosis or medical history of both lower extremities; 4. Those who have pre-storage autologous blood transfusion or those who require the use of blood transfusion devices; 5. Those with contraindications to the use of tranexamic acid or low molecular weight heparin; 6. Can not cooperate with the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss;Blood routine;Subcutaneous ecchymosis rate;Surgical limb circumference change rate;Occurrence of thrombus-related events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale function score;American hospital for special surgery knee score; | — |
Countries
China
Contacts
Public ContactTao Qifeng
Panzhihua Central Hospital
Outcome results
None listed