sepsis
Conditions
Interventions
Group 1:Meropenem
Group 2:Amoxicillin
Healthy group:None
Sponsors
Peking University Third Hospital Drug Clinical Trial Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Neonates aged <=28 days after birth (including premature and full-term neonates), no gender limit; 2. The legal representative of the research subject can maintain good communication with the researcher and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those born with congenital genetic metabolic diseases; 2. Congenital abnormalities of the kidneys and urethra, including renal hypoplasia/dysplasia, posterior urethral valves and other congenital abnormalities of the kidneys and urethra; 3. Patients with cystic kidney disease; 4. Patients with congenital nephrotic syndrome; 5. Bilateral renal vein thrombosis or renal artery thrombosis and renal infarction caused by improper placement of umbilical artery catheter; 6. Patients with urethral stricture and indwelling catheterization dysfunction caused by traumatic bladder catheterization; 7. There are major diseases such as serious hematological diseases, tumors, and immune diseases; 8. Those suffering from pyridoxine-dependent epilepsy and taking vitamin B6; 9. Those who have any other factors considered inappropriate by the pediatrician to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maximum concentration (Cmax);time to achieve maximum concentration (Tmax);elimination rate (CL); | — |
Countries
China
Contacts
Public ContactLiu Dongyang
Peking University Third Hospital Drug Clinical Trial Center
Outcome results
None listed