None listed
Conditions
Interventions
Group P:Propofol + normal saline
Group S:Propofol + sufentanil
Group E:Propofol + esketamine
Group L:Propofol + low-dose esketamine
Sponsors
Shenzhen Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Patients who have undergone painless gastrointestinal endoscopy; 3. ASA classification I-III; 4. In line with ethics, the patients were tested voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to conventional endoscopic operations; 2. Patients with severe heart disease, such as cyanotic heart disease, congenital heart disease with pulmonary hypertension, malignant arrhythmia, cardiac function grade 3-4, etc.; 3. Difficult airway and severe respiratory disease (obstructive sleep apnea syndrome, mouth opening disorder, restricted neck or jaw movement, morbid obesity, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 4. Those suffering from mental or nervous system diseases or suspected dementia or memory impairment; 5. Severe impairment of auditory, visual and language system functions; 6. Critically ill patients with severe liver and kidney disease (Child-Pugh class C or preoperative dialysis patients); 7. Those with preoperative cognitive dysfunction determined by the MMSE scale; 8. Confirmed/suspected of abuse or long-term use of narcotic sedative analgesics; 9. Those who have contraindications or allergies to experimental drugs and other anesthetic drugs; 10. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions during gastroenteroscopy; | — |
Countries
China
Contacts
Public ContactLiu Youtan
Southern Medical University Shenzhen Hospital
Outcome results
None listed