Effect of different intraoperative inhaled oxygen concentrations on short-term neurocognitive function after off-pump coronary artery bypass grafting: a prospective study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053835

Enrollment

Unknown

Registered

2021-12-01

Start date

2023-03-01

Completion date

Unknown

Last updated

2023-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group A:Minimum 30% oxygen concentration

Group B:Minimum 80% oxygen concentration

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Aged 50-85 years; 2. ASA III-IV grade; 3. To perform off-pump coronary artery bypass grafting.

Exclusion criteria

Exclusion criteria: 1. Acute coronary syndrome; 2. Severe cognitive impairment, baseline MoCA-BC score <19; 3. Right-to-left shunt heart disease patients; 4. Do not agree to participate in the research; 5. Congestive heart failure; 6. Hearing impairment; 7. Single-lung ventilation

Design outcomes

Primary

Measure	Time frame
Montreal Cognitive Functioning Score on Postoperative Day 2 (Basic Chinese version);	—

Secondary

Measure	Time frame
Postoperative delirium;Myocardial infarction;Postoperative cerebral infarction;Pain score;Cough/respiratory difficulty;ICU duration;Length of hospital stay;In-hospital mortality;Montreal Cognitive Functioning Score on Postoperative Day 7(Basic Chinese version);Montreal Cognitive Functioning Score on Postoperative Day 14(Basic Chinese version);Montreal Cognitive Functioning Score on Postoperative Day 21(Basic Chinese version);Montreal Cognitive Functioning Score on Postoperative Day 28 (Basic Chinese version);	—

Measure

Time frame

Postoperative delirium;Myocardial infarction;Postoperative cerebral infarction;Pain score;Cough/respiratory difficulty;ICU duration;Length of hospital stay;In-hospital mortality;Montreal Cognitive Functioning Score on Postoperative Day 7(Basic Chinese version);Montreal Cognitive Functioning Score on Postoperative Day 14(Basic Chinese version);Montreal Cognitive Functioning Score on Postoperative Day 21(Basic Chinese version);Montreal Cognitive Functioning Score on Postoperative Day 28 (Basic Chinese version);

—

Countries

China

Contacts

Public ContactFang Jun

The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)

fjjf123@sina.com+86 131 7001 0298

Outcome results