Osteoarthritis of hip and knee
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 40 to 70 years; 2. The joint pain lasts for more than 6 months and the joint pain is most of the time in the last month; 3. X-ray shows Kellgren and Lawrence grade 2 or 3 osteoarthritis; 4. MRI shows that the maximum diameter of the subchondral cystic lesion of the joint is not less than 1cm and is accompanied by BML (greater than or equal to grade 1).
Exclusion criteria
Exclusion criteria: 1. Kellgren and Lawrence Level 1 or 4; 2. The affected knee has been injected with glucocorticoid or hyaluronic acid within the past 6 months; 3. The joint has undergone surgery or other operations are planned for the joint; 4. Suffering from other diseases such as: systemic or inflammatory joint disease (rheumatoid arthritis), a history of crystalline or neurological joints, other muscle, joint or nervous system diseases that affect the function of the lower limbs; 5. There is immunosuppression or acute infection; 6. Suffering from or had suffered from malignant tumor; 7. Have any other medical conditions that cannot participate in the study, including contraindications to MRI, such as pacemakers; 8. Pregnancy; 9. Body mass index (BMI) > 40 kg/m^2; 10. Inability to understand written and spoken Chinese; 11. History of any mental and psychological illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-month body mass index level; | — |
Countries
China
Contacts
The Sixth People's Hospital Affiliated to Shanghai Jiaotong University