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Efficacy of collagen sponge versus collagen membrane in combination with collagenated bovine bone mineral on ridge preservation of compromised extraction sockets in periodontitis patients: a randomized controlled clinical trial

Efficacy of collagen sponge versus collagen membrane in combination with collagenated bovine bone mineral on ridge preservation of compromised extraction sockets in periodontitis patients: a randomized controlled clinical trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053766
Enrollment
Unknown
Registered
2021-11-29
Start date
2021-12-01
Completion date
Unknown
Last updated
2022-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontitis

Interventions

Experimental group:collagen sponge + collagenated bovine bone mineral
control group:collagen membrane + collagenated bovine bone mineral

Sponsors

Affiliated Stomatological Hospital of Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 years; 2. For molars that cannot be preserved due to periodontitis, late implantation is planned in the later stage; 3. There is no acute infection at the surgical site, such as abscess or periodontal discharge; 4. There are bone defects in 1 to 2 bone walls of the extraction socket, the alveolar bone of the defect bone wall is absorbed to 1/2 or less of the middle root, and the remaining height is >=3mm; 5. At least one adjacent tooth is present.

Exclusion criteria

Exclusion criteria: 1. Smoking; 2. During pregnancy or lactation; 3. Untreated periodontal disease; 4. Poor general health and unable to tolerate surgery (such as diabetes, heart disease, malignant tumor, etc.); 5. Past history of radiotherapy or radiotherapy; 6. Systemic diseases or drug use that affect bone metabolism or bone healing and mucosal healing (such as immunosuppressants, phenytoin, bisphosphonates, etc.); 7. Continuous extraction of multiple teeth; 8. Hypersensitivity to the materials used in the study.

Design outcomes

Primary

MeasureTime frame
horizontal width of ridge;vertical height of ridge;

Secondary

MeasureTime frame
width of keratinized tissue;thickness of mucosa;postoperative pain;

Countries

China

Contacts

Public ContactDing Peihui

Affiliated Stomatological Hospital of Zhejiang University School of Medicine

phding@zju.edu.cn+86 18957108518

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026