Lung cancer
Conditions
Interventions
Control group:None
Experimental group1:0.25% ropivacaine
Experimental group2:0.5% ropivacaine
Experimental group3:0.75% ropivacaine
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 20 to 70 years; 2. BMI 18.5-24.9; 3. ASA I-III level; 4. No body pain in the past month and no pain medication; 5. Operation time > 1h; 6. No history of chronic pain.
Exclusion criteria
Exclusion criteria: 1. Allergy to local anesthetics; 2. Severe cardiovascular and cerebrovascular diseases; 3. Preoperative pulmonary function decline: the preoperative FRC is less than 50% of the predicted value and or the forced vital capacity in the first second is less than 50%; 4. Abnormal liver and kidney function before surgery (creatinine greater than 1.5 mg/dl, aspartate or aspartate aminotransferase greater than 40 U/l); 5. The patients received ARB, ACEI, calcium ion antagonist, NO, sildenafil and other drugs before surgery; 6. Patients are unwilling to sign informed consent; 7. Hearing or visual impairment cannot communicate; 8. The operation time is too short; 9. DLCO < 50%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial partial pressure of oxygen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mixed venous oxygen saturation; | — |
Countries
China
Contacts
Public ContactZhou Jianwen
Shanghai Chest Hospital
Outcome results
None listed