Infection of Helicobacter pylori
Conditions
Interventions
Experimental group1:Lactobacillus paracasei
Experimental group2:Lactobacillus fermentum
Experimental group3:Lactobacillus crispatus
Experimental group4:Lactobacillus rhamnosus +HA
Experimental group5:Hyaluronic acid
Sponsors
Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with Helicobacter pylori infection within 12 months of enrollment through 14C-urea breath test, rapid urease test or histological examination; 2. Aged 18 to 65 years, half male and half male; 3. The general health status is good, but whether eradication treatment is required according to the judgment of the investigator; 4. The ability to understand the learning requirements and commit to cooperate with the research throughout the experimental period; 5. Willing to provide written informed consent and basic situation questionnaire; 6. No previous anti-pyloric therapy.
Exclusion criteria
Exclusion criteria: 1. History of gastrointestinal surgery (except appendectomy); 2. Allergy to triple antibiotics or any contraindication to eradication therapy; 3. Pregnant or lactating women; 4. Any history of serious diseases (severe cardiovascular, endocrine, liver and kidney dysfunction, etc.) before the eradication of Helicobacter pylori treatment; 5. Patients will also be excluded if they have taken probiotics, antibiotics or investigational products, respectively, in the month prior to inclusion; 6. Mental illness, which may lead to difficulties in cooperation; 7. Patients who lack self-judgment ability; 8. Alcohol or drug abusers; 9. Subjects participating in other clinical trials; 10. For the purpose of the researcher's notice to the researcher; 11. Those who do not meet the research requirements or the researchers believe that they should not participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 14C breath test;Fecal Metagenome;anti-Hp IgG;TNF-a;Serum cytokines; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biochemical examination;Blood routine examination; | — |
Countries
China
Contacts
Public ContactZhai Qixiao
School of Food Science and Technology, Jiangnan University
Outcome results
None listed