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Impact of remote limb ischemic conditioning on aneurysmal subarachnoid hemorrhage cognitive impairment and the underlying mechanism

Impact of remote limb ischemic conditioning on aneurysmal subarachnoid hemorrhage cognitive impairment and the underlying mechanism

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053696
Enrollment
Unknown
Registered
2021-11-27
Start date
2021-11-29
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aneurysmal subarachnoid hemorrhage

Interventions

intervention group:LRIC with 200mmHg
control group:sham LRIC 60mmHg

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 years; 2. Those diagnosed with aneurysmal subarachnoid hemorrhage by cranial MRI, cranial CTA or whole cerebral angiography; 3. The patient was admitted to the hospital within 72 hours of the onset, and the responsible aneurysm was treated by embolization and/or clipping; 4. The patient or family members gave informed consent and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Those with progressive neurological disease before enrollment; 2. Those who have neurological dysfunction caused by neurological disease or brain trauma in the past; 3. Severe heart, liver, kidney disease, or various tumors, immune, blood and connective tissue system diseases; 4. The ruptured aneurysm has not been treated or cannot be treated; 5. Those with severe trauma or major surgery within the past 6 months; 6. Upper limb soft tissue injury, venous thrombosis, infection and skin damage; 7. Those who cannot cooperate during the operation; 8. Those whose remaining life expectancy is less than 1 year; 9. Those who cannot complete the follow-up.

Design outcomes

Primary

MeasureTime frame
Montreal Cognitive Assessment;Mini-Mental State Examination;cerebral autoregulation;

Secondary

MeasureTime frame
lipoxin 4;Nitric oxide;reactive oxygen species;

Countries

China

Contacts

Public ContactGuo Zongduo

The First Affiliated Hospital of Chongqing Medical University

stonegzd@163.com+86 13594118695

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026