Donor-derived infection in lung transplantation
Conditions
Interventions
Donor CARBA-R detection group:GeneXpert and CARBA-R kit were used to detect the donor before lung transplantation
Control lung transplantation group:GeneXpert combined with Carba-R kit was not used to detect CRO infection in donor lungs and received lung transplantation
Sponsors
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for donor lungs (all criteria are met): the same as the recipient's ABO blood type, or different but compatible; donor aged 18 to 70 years old; oxygenation index (P/F) > 250 mmHg (FiO2= 1.0, PEEP=5cmH2O); chest X-ray lung field is clear or there is a small to moderate amount of exudation; organ donor and recipient are well matched or poorly matched, but donor lung volume reduction or lobe transplantation can be performed according to specific conditions ; The donor has no chest trauma or there is chest trauma but the lung oxygenation is satisfactory; the donor has no or slight aspiration; no purulent secretions in the airway or the presence of purulent secretions improves after treatment and maintenance; the donor lung Cold ischemia time < 12 hours; 2. Inclusion criteria for recipients: age of recipients <=75 years old; normal or mildly abnormal liver and kidney functions.
Exclusion criteria
Exclusion criteria: 1. Donor lung exclusion criteria (meeting one of the criteria): Legal documents such as organ donation confirmation cannot be obtained; microbial culture confirms that the donor has pan-drug-resistant or pan-drug-resistant bacterial infection; 2. Receptor exclusion criteria: immunosuppressed state; severe dysglycemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRO-related DDI incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of infection-related serious complications;Mortality of infection-related severe complications;Intensity of antibiotic use;length of hospital stay;Health economic indicators; | — |
Countries
China
Contacts
Public ContactZhou Wenyong
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University
Outcome results
None listed