Comparison of intra-articular ozone combined with hyaluronic acid injection and platelet rich plasma injection in the treatment of knee osteoarthritis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053667

Enrollment

Unknown

Registered

2021-11-27

Start date

2021-12-01

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

Group O3+HA:Trioxide + sodium hyaluronate

Group PRP:Platelet-Rich Plasma

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Kellgren-Lawrence Level 2-3; 2. Aged 45-75 years; 3. Body mass index BMI < 30kg/m^2; 4. The knee joint is stable without dislocation.

Exclusion criteria

Exclusion criteria: 1. Combined with malignant tumor; 2. Combined with mental disorders; 3. Coagulation disorders or anticoagulation therapy; 4. Serious damage to liver, kidney, heart and lung functions; 5. Recent history of knee injury; 6. Any intra-articular injection within the past year; 7. Injection site infection.

Design outcomes

Primary

Measure	Time frame
Western Ontario and McMaster University Osteoarthritis Index;	—

Secondary

Measure	Time frame
International Knee Documentation Committee score;Biochemical index;Adverse reaction;	—

Countries

China

Contacts

Public ContactLiu Lei

Liaocheng People's Hospital

zhuliulei@163.com+86 15063523057

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026