Study of the prediction of volume responsiveness in mechanically ventilated hypotensive patients - the application value of central venous oxygen saturation and left ventricle-arterial coupling

Central venous oxygen saturation and left ventricular-arterial coupling predict volume responsiveness in mechanically ventilated hypotensive patients

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100053665

Enrollment

Unknown

Registered

2021-11-27

Start date

2021-12-01

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotensive patients

Interventions

Case series:Nil

Eligibility

Sex/Gender

Male

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age greater than 18 years; 2. Circulatory shock: SBP/DBP is lower than 90/60mmHg or MAP is lower than 65mmHg; or blood pressure is decreased by > 40mmHg; 3. Mechanical ventilation, without breathing effort; 4. Fluid therapy is needed.

Exclusion criteria

Exclusion criteria: 1. Acute myocardial infarction, acute heart failure and other disease states that do not require fluid replacement; 2. Poor ultrasound imaging or intolerance to echocardiography; 3. Cardiac assist devices such as ECMO, IABP or pacemaker that affect the assessment of ventricular-arterial coupling; 4. No central venous catheter; 5. Aortic valve replacement (affecting VTI measurement); 6. Those who refuse to participate in the experiment.

Design outcomes

Primary

Measure	Time frame
Fluid responsiveness;	—

Countries

China

Contacts

Public ContactZhou Xiaoyang

Ningbo Huamei Hospital, University of Chinese Academy of Sciences

zhouxiaoyang_1990@163.com+86 18268560726

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026