Obstructive sleep apnea
Conditions
Interventions
healthy control group, OSA patients without type 2 diabetes and OSA patients with type 2 diabetes :Nil
Sponsors
University of Hong Kong-Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. According to the "American Academy of Sleep Medicine Clinical Practice Guidelines - Clinical Practice Guidelines for the Diagnosis of Obstructive Sleep Apnea", OSA was diagnosed based on the clinical manifestations of the subjects and the results of polysomnography, and the sleep apnea index (AHI) >= 5. 1530 is severe OSA; 2. Diabetes group: Diabetes symptoms (typical symptoms include polydipsia, polyuria, and unexplained weight loss) plus one of the following 3 are diagnostic: (1) Random blood sugar (referring to blood sugar at any time of day) >= 11.1 mmol/L (200mg%); (2) Fasting blood glucose (fasting state refers to no calorie intake for at least 8 hours) >= 7.0 mmol/L (126 mg%); (3) Blood glucose >= 11.1 mmol/L (200 mg%) 2 hours after glucose loading.
Exclusion criteria
Exclusion criteria: 1. Chronic obstructive pulmonary disease, upper respiratory tract infection, tumor, hypertension, cardiovascular disease, mental disease, autoimmune disease, kidney disease; 2. Frequent use of drugs that may interfere with glucose metabolism or the HPA axis, sedatives or narcotics, alcohol and drug abuse; 3. There is a history of OSA treatment before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adropin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor Necrosis Factor-a (TNF-a);Interleukin 6 (IL-6);High sensitive C-reactive protein (hsCRP);polysomnography; | — |
Countries
China
Contacts
Public ContactJi Yang
University of Hong Kong-Shenzhen hospital
Outcome results
None listed