Effect of aminophylline on postoperative pulmonary complications in elderly patients undergoing total hip arthroplasty

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053651

Enrollment

Unknown

Registered

2021-11-26

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transcervical fracture

Interventions

Group C:5%GS, 40ml

Group A1:Aminophylline 2.5mg/Kg+5%GS, 40ml

Group A2:???5mg/Kg+5%GS,40ml

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective hip replacement surgery under general anesthesia; 2. ASA classification I~III; 3. Aged >= 60 years.

Exclusion criteria

Exclusion criteria: 1. Long-term application of theophylline antiasthmatic drugs before surgery; 2. Uncontrolled diabetes, long-term use of glucocorticoids; 3. Refuse to participate in the trial or to sign the informed consent; 4. Postoperative patients are sent to ICU with a tube; 5. Severe obstructive sleep apnea; 6. Preoperative disturbance of consciousness and cognitive dysfunction; 7. Abnormal lung function, obvious abnormal chest imaging examination; 8. Severe liver and kidney disease; 9. Patients with bilateral total hip replacement surgery; 10. Patients with cardiac insufficiency and arrhythmia; 11. Patients with history of hypoxemia, hypertension or peptic ulcer.

Design outcomes

Primary

Measure	Time frame
Postoperative incidence of pulmonary complications;	—

Countries

China

Contacts

Public ContactLiu Su

Tongshan People's Hospital

150040009@qq.com+86 18118309692

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026