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The effects of low-dose remifentanil on traction pain and umbilical cord serum-derived exosomes in repeated ceserean section maternal

The effects of low-dose remifentanil on umbilical cord serum-derived exosomes in parturient undergoing epidural anesthesia

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053635
Enrollment
Unknown
Registered
2021-11-26
Start date
2021-11-26
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delivery

Interventions

Group R:Remifentanil is given a slow intravenous push
Group E:Epidural anesthesia was performed

Sponsors

The First Affiliated Hospital of Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Aged 20 to 40 years, height 150-170cm, weight 50-80kg, ASAI or II grade, BMI<35kg/m^2, same group of surgeons for second cesarean section; 2.The parturient is easy to communicate and has no serious dysfunction of important organs; 3.Puerpera and their family members agree to participate in the study.

Exclusion criteria

Exclusion criteria: 1.Maternal simple intelligence examination score < 24 points; 2.Patients with abnormal liver, kidney and other important organs; 3.Patients with severe vision or hearing impairment; 4.Patients who have taken analgesic, sedative or antidepressant drugs for a long time; 5.Suspicious preoperative sleep quality or severe insomnia (AIS score greater than or equal to 4 points); 6.Patients with severe bradycardia (HRG <= 50 beats/min), hypotension (preoperative SBP <= 90mmHg) or abnormal heart rhythm; 7.Patients with a history of endocrine system disorders, mental disorders or allergic diseases; 8.Complications related to obstetrics and contraindications of epidural anesthesia; 9.Have a history of research drug allergy.

Design outcomes

Primary

MeasureTime frame
Exosomes;Visual analog pain score;Sedation scores;Vital signs;Neonatal score;Blood gas analysis;

Secondary

MeasureTime frame
Maternal satisfaction;Adverse reactions;

Countries

China

Contacts

Public ContactXiong Xiangqing

The First Affiliated Hospital of Wenzhou Medical University

471314122@qq.com+86 13906631675

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026