Recurrent spontaneous abortions/recurrent implantation failure
Conditions
Interventions
Treatment group:Autologous decidual-like NK cells
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
Female
Age
22 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Aged 22 to 40 years, with clear fertility desires, but unexplained recurrent spontaneous abortions or repeated implantation failure that occurred before 12 weeks of pregnancy, and meet the following conditions: (1)Normal ovarian function or with frozen embryos; (2)Endometrium thickness measured by vaginal ultrasound before ovulation or at mid-luteal phase >= 7mm; 2.18 kg/m^2<BMI<30 kg/m^2; 3.With abnormal endometrial NK cells. (In this study, it is defined as the proportion of CD3-CD56+ natural killer cells (NK) in CD45+ lymphocytes in the menstrual blood of patients is less than 19.4%, which meets that the proportion of CD49a+NK cells in NK cells is less than 50% or the proportion of CD49a+CD16- NK is less than 40%); 4.Normal thyroid function; 5.Patients and their family members voluntarily participated in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe immediate allergy to any types of drugs ; 2.In the period of using progesterone receptor modulator Asoprisnil or related drugs; 3.Chromosomal karyotype abnormalities in one spouse; 4.Severe endometriosis, uterine fibroids affecting the shape of the uterine cavity or the size of the whole uterus more than 2 and a half months of pregnancy, uterine malformation, uterine adhesion or thin endometrium; 5.Vaginitis and endometritis; 6.With autoimmune diseases, such as SLE, APS, etc.; 7.Abnormal blood coagulation function, abnormal liver and kidney function, or other basic diseases (uncontrolled hypertension, diabetes, thyroid disease, sexually transmitted diseases, etc.) that the researcher thought may affect the progress of the research; 8.History of pelvic malignant tumors or after receiving radiotherapy; 9.Bad habits such as smoking, alcohol abuse, excessive coffee drinking, drug abuse, etc. 10.Unfavorable environmental factors, such as excessive exposure to harmful chemical substances, excessive exposure to radiation, etc.; 11.Depression and other mental illnesses, having bad emotions, causing nervousness and negative emotions, depression, etc.; 12.Unable to adhere to the hospital examination and follow-up, or other treatment during the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ratio of CD49a+ NK cells; | — |
Countries
China
Contacts
Public ContactHu Yali
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed