Digestive system disease
Conditions
Interventions
Experimental group:Ciprofol induction
Sponsors
Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Institute of Anesthesiology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years, gender-unrestricted; 2.American Anesthesiologist Classification (ASA) Grade I-II; 3.Body Mass Index (BMI) >= 18 and = 95% when breathing air; systolic blood pressure (SBP) >= 90mmHg and = 60mmHg and = 55 and <= 100 beats/min; 5.Understand the study process and methods, and voluntarily participate in the study.
Exclusion criteria
Exclusion criteria: 1.Patients with contraindications to general anesthesia or those with a previous history of accidental anesthesia; 2.Patients who are known or suspected to be or contraindication to propofol injection, cypofol injection excipients, benzodiazepines, opiates, myisolins and so on; 3.Patients with combined brain loss, intracranial hypertension, stroke, unstable angina pectoris, and myocardial infarction; 4.Respiratory insufficiency, obstructive pulmonary disease, difficult airway, or judged difficult tracheal intubation (Mallampati III or IV); 5.Uncontrolled diabetes mellitus or hypertension; 6.Severe liver dysfunction or severe renal insufficiency; 7.History of alcohol abuse or drug dependence; 8.Abuse or long-term application of anesthetic, sedative and analgesic drugs; 9.A previous history of mental illness; 10.Patients who have participated in any drug clinical trial within 1 month before the screening; 11.Pregnancy and lactating women; fertile women or men are unwilling to have contraception throughout the trial; subjects with pregnancy plans (including males) within 1 month after the trial; 12.Subjects who have any other factors that the investigator considers inappropriate for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia induction success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of successful induction of anesthesia;Eyelash reflection disappear time;Changes in the bispectral index of electroencephalogram;Duration of operation, duration of intubation (from intubation to extubation), duration of stay in monitoring treatment room after anesthesia (modified AIdrete score >=9 points);Study the use of drugs and alternative medicines (including frequency and dosage);Evaluation of anesthesia induction physician satisfaction; | — |
Countries
China
Contacts
Public ContactWang Chenxu
Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Institute of Anesthesiology
Outcome results
None listed