Diuretic resistance in heart failure
Conditions
Interventions
Gold Standard:1. The diagnostic criteria for heart failure are based on the "China Heart Failure Diagnosis and Treatment Guidelines 2018" and the 15th edition of "Practical Internal Medicine"
2. The standard of diuretic resistance should refer to "Expert Recommendations for Volume Management of Heart Failur"
ACQUITY 
UPLC 
M-Class 
and 
Peptidomics, 
Tof.
Sponsors
Hu'nan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. All meet the diagnostic criteria of Western medicine for heart failure, and patients with diuretic resistance meet the criteria for diuretic resistance; 2. Aged 50-90 years; 3. New York Heart Association Cardiac Function Class (NYHA) >= grade III.
Exclusion criteria
Exclusion criteria: 1. Anuria (daily urine volume 265.2µmol/L); hypokalemia (serum potassium 5.5 mmol/L), severe hypotension (recumbent systolic blood pressure 120 beats/min); 4. Malignant tumor, end-stage renal failure, severe hepatic insufficiency, autoimmune disease, moderate anemia of uncontrolled adrenal function (hemoglobin < 90 g/L); 5. Pregnant and lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood and urine metabolomics;Blood and urine polypeptide omics; | — |
Countries
China
Contacts
Public ContactLiang Hao
Hu'nan University of Traditional Chinese Medicine
Outcome results
None listed