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To explore the effect mechanism of Taijiquan in the treatment of knee osteoarthritis from the perspective of rehabilitation omics

To explore the effect mechanism of Taijiquan in the treatment of knee osteoarthritis from the perspective of rehabilitation omics

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053574
Enrollment
Unknown
Registered
2021-11-24
Start date
2021-12-15
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis (KOA)

Interventions

Optimize Tai Chi group:Optimize Tai Chi
Ten-style Tai Chi group:Yang's Ten Styles of Tai Chi

Sponsors

Fujian University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria for professional Tai Chi athletes: (1) Martial arts first-level athlete and above; (2) Aged 50-80 years, have received regular Taijiquan martial arts routine training for >= 10 years; (3) Good health, no history of lower extremity joint disease; (4) No lower extremity joint pain during Tai Chi training or after training; (5) Taijiquan practice times >= 3 times per week after retirement, and each training session is >= 60 minutes; (6) Those who participated voluntarily and signed the informed consent form. 2. Inclusion criteria for long-term Tai Chi practitioners: (1) Aged 50-80 years; (2) The number of Taijiquan exercises per week is >= 3 times, each training session is >= 60 minutes, and the boxing age is >= 10 years; (3) There is no lower extremity joint pain during or after Tai Chi training; (4) Good health, no history of lower extremity joint disease; (5) Those who participated voluntarily and signed the informed consent form. 3. Inclusion criteria for those without KOA symptoms: (1) Those who have no symptoms and diagnosis of knee osteoarthritis after diagnosis by clinicians; (2) Aged 50-80 years; (3) Have no previous experience in Taijiquan practice, and have only started practicing Taijiquan in the past three months and mastered the Taiji Duan Duanquan (Yang's Eight-style Taijiquan) created by the State Sports General Administration; (4) There is no lower extremity joint pain during or after Tai Chi training; (5) The number of Tai Chi exercises per week is >= 3 times, and each training session is >= 60 minutes; (6) Those who participated voluntarily and signed the informed consent form. 4. KOA inclusion criteria: (1) Meet the clinical diagnostic criteria for knee osteoarthritis; (2) Imaging diagnosis of knee osteophyte formation; (3) Aged 50-80 years; (4) The K/L grading of knee X-ray films is grade 1-4, and the person can independently walk on level ground for at least 8 meters and go up and down 8 steps; (5) The knee joint VAS score in daily activities within 1 week before the test is 10-60mm; (6) Maintain the original daily dietary pattern during the trial period and avoid major changes; (7) Those who participated voluntarily and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Various acute, infectious, infectious diseases, visceral insufficiency; 2. Other diseases of the nervous system and musculoskeletal system affect gait, such as stroke, fracture, rheumatoid arthritis, plantar fasciitis, low back pain, etc.; 3. Those who have used non-steroidal anti-inflammatory drugs or corticosteroids within 24 hours before the test; have received drug treatment, modern or traditional Chinese medicine rehabilitation methods within the past 2 weeks; those who have undergone intra-articular steroid injection or arthroscopic surgery within the past 3 months and have a history of surgery; have undergone intra-articular hyaluronic acid injection within the past 6 months; are planning to undergo total knee replacement within 1 year; 4. Long-term regular aerobic exercise (>= 3 times a week for more than 3 months is a long-term regularity); 5. Severe cognitive impairment [Montreal Cognitive Assessment (MoCA < 18 points)]; 6. Those who cannot cooperate with evaluation and treatment.

Design outcomes

Primary

MeasureTime frame
Gait analysis;EMG;Metabolic biomarkers;Muscle strength;Muscle mass;

Secondary

MeasureTime frame
The Western Ontario and McMaster University Osteoarthritis Index;Knee Injury and Osteoarthritis Outcome Score;Kinesiophobia;Symptoms and Signs/Traditional Chinese Medicine Syndrome Score;

Countries

China

Contacts

Public ContactWang Xiangbin

Fujian University of Traditional Chinese Medicine

wangxbin@fjtcm.edu.cn+86 18606019377

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026