ischemic stroke
Conditions
Interventions
case series:none
Sponsors
Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. The admission diagnosis was the first acute cerebral infarction (confirmed by CT or MR).
Exclusion criteria
Exclusion criteria: 1. Past history of dementia. 2. This NIHSS score is greater than or equal to 15 points. 3. There are other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 4. Other systemic diseases with unstable vital signs or cognitive impairment: liver and renal insufficiency, rheumatoid arthritis (abnormal serum inflammatory markers), abnormal thyroid function, severe anemia, folic acid and vitamin B12 deficiency, specific infections (eg, syphilis, HIV), alcohol and drug abuse, others (to be discussed with the team). 5. There is mental and neurodevelopmental delay. 6. The presence of other diseases known to cause cognitive impairment. 7. Severe heart and lung diseases (myocardial infarction, heart failure, hypertrophic cardiomyopathy). 8. There are contraindications to MRI. 9. Suffering from diseases that cannot cooperate with the completion of cognitive examinations (aphasia, hand paralysis (muscle strength less than grade 3). 10. Refusing to draw blood. 11. Refused to sign the informed consent during the baseline period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Alanine aminotransferase;Total protein;Albumin;Direct bilirubin;Total bilirubin;Total cholesterol;Triglycerides;Homocysteine;Creatinine;Urea;Uric acid;C reactive protein;Vitamin B12;Folic acid;Troponin T;Free triiodothyronine;Free thyroxine;Thyroid stimulating hormone;Human immunodeficiency virus antigen antibody;Syphilis spiral antibody;Prothrombin time;Activated partial thromboplastin time;D-dimer;Creatine kinase isoenzyme;Myoglobin;Brain natriuretic peptide;High-sensitivity troponin T; | — |
Countries
China
Contacts
Public ContactWang Xiang
Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed