HIV-infected patients with intestinal disease
Conditions
Interventions
Control Group:Only ART
Bifidobacterium Group:ART combined with bifidobacteria and Lactobacillus triplex viable tablets
Bacillus Subtilis Group:ART combined with Bacillus subtilis erectile enteric-soluble capsule
Sponsors
Chongqing Public Health Medical Center
Eligibility
Sex/Gender
All
Age
17 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed patients who meet the diagnostic criteria of AIDS and are accompanied by diarrhea, abdominal distension, abdominal pain, abdominal belching, constipation, tenesmus and other intestinal-related symptoms; 2. Aged 18-70 years; no gender limit; 3. Have not received probiotics, prebiotics and other treatments recently; 4. Living and eating regularly, the condition is relatively stable; 5. No major comorbidities; 6. Communication is barrier-free and compliance is good; 7. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the test drug or have serious side effects and cannot tolerate it; 2. Pregnant and lactating patients; 3. Those with severe heart, lung, liver, kidney and other diseases who are not suitable for colonoscopy and intestinal biopsy; 4. Combined with opportunistic infection, inflammatory bowel disease, intestinal Behcet's disease, intestinal tumor, etc.; 5. Participated in other clinical studies recently; 6. Taking drugs that have a significant impact on the intestinal barrier in the past four weeks, such as metformin, sulfonamides, antibiotics, antifungal drugs, etc.; 7. Other factors that may have a significant impact on the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression of tight junction related proteins Claudin-1, Occludin and ZO-1 in intestinal tissue before and after treatment ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Expression of intestinal immune inflammatory factors before and after treatment;Comparison of safety before and after treatment;Plasma midgut mucosal injury/microbial translocation before and after treatment; | — |
Countries
China
Contacts
Public ContactRong Li
Chongqing Public Health Medical Center
Outcome results
None listed