Lupus Nephritis
Conditions
Interventions
Corticosteroids + CTX group:Corticosteroids + cyclophosphamide
Corticosteroids + MMF group:Corticosteroids + mycophenolate mofetil
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 5-18 years; 2. Meet the 1997 American Rheumatology Association diagnostic criteria for systemic lupus erythematosus; 3. 24-hour urine protein quantification > 1g; 4. Renal biopsy was performed within 6 months before enrollment, according to the pathological classification criteria of lupus nephritis jointly revised by the International Society of Nephrology and the Society of Renal Pathology in 2003, the patients were diagnosed as type III, type III+V, type IV, type IV+V.
Exclusion criteria
Exclusion criteria: 1. Estimated glomerular filtration rate < 30ml/min·1.73m^2; 2. Lupus encephalopathy; 3. Severe cardiopulmonary insufficiency; 4. Suffered from pancreatitis or gastrointestinal bleeding within 3 months before enrollment; 5. Active gastric ulcer within 3 months before enrollment; 6. Regular use of immunosuppressive agents within 3 months before enrollment; 7. There are contraindications to mycophenolate mofetil, cyclophosphamide or hormones; 8. Allergy to mycophenolate mofetil, cyclophosphamide or hormones; 9. Other conditions deemed inappropriate by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-month complete remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6-month partial response rate;Time to remission;Adverse event rate;Systemic Lupus Erythematosus Disease Activity Index; | — |
Countries
China
Contacts
Public ContactJiang Xiaoyun
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed