spina bifida
Conditions
Interventions
Gold Standard:Autopsy after labor induction or MRI after birth confirmed closed spina bifida
of 
spina 
bifida 
using 
spine 
width, 
conic 
and 
scoliosis 
angle
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Part I Inclusion Criteria: (1) There is no age limit for pregnant women, and the gestational week is 22-28w; (2) A section of the spine facing the maternal abdominal wall can be obtained; (3) Satisfactory 3D reconstructed images can be obtained; (4) The case group requires prenatal ultrasound to be suspected of fetal sacrococcygeal closed spina bifida, or lumbosacral closed spina bifida confirmed by labor induction or other imaging studies (X-ray, MRI or CT) after birth, follow-up for 1 year after birth; (5) The control group randomly selected 80 cases of fetuses in the second trimester of the same period with no abnormal fetuses found in the fetal system screening, all of which were confirmed to be normal after delivery. 2. The second part of the inclusion criteria: (1) There is no age limit for pregnant women, and the gestational week is 22-28w; (2) A section of the spine facing the maternal abdominal wall can be obtained; (3) Satisfactory 3D reconstructed images can be obtained; (4) Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. The first part of the exclusion criteria: (1) The clinical information of pregnant women is missing; (2) Combined with congenital diseases unrelated to CSB; (3) The quality of the imaging data of pregnant women could not meet the analysis standard. 2. The second part of the exclusion criteria: (1) The clinical information of pregnant women is missing; (2) Combined with congenital diseases unrelated to CSB; (3) The quality of the imaging data of pregnant women cannot meet the analysis standard; (4) Participate in other clinical researches.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intervertebral space measurement;Cone position;Spine curvature; | — |
Countries
China
Contacts
Public ContactZhang Weiping
The First Affiliated Hospital of Nanchang University
Outcome results
None listed