spesis
Conditions
Interventions
Experimental group:Sodium Bicarbonate Ringer's
Control group:Normal Saline
Sponsors
Yangzhou Jiangdu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years; 2. Sepsis (sepsis 3.0 criteria) within 24 hours of diagnosis; 3. The patient himself or his legal guardian voluntarily signed the informed consent (within 24 hours after enrollment).
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding; 2. End-stage renal disease requires maintenance hemodialysis; 3. Renal replacement therapy has been or is expected to be performed within 6 hours; 4. Has been included in this study; 5. Expected to die within 24 hours; 6. Other conditions deemed inappropriate by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major renal adverse events within 30 days;Polysaccharide coating;Shock reversal time;ICU mortality;The amount of NaHCO3 used during ICU due to acid correction;Cumulative dose and duration of vasoactive drugs in ICU;ICU utilization rate of mechanical ventilation, days of use, days without mechanical ventilation within 30 days;ICU hospital stay and total stay;The incidence of drug-related adverse events;Incidence of hyperchloremia, hypernatremia, and metabolic alkalosis; | — |
Countries
China
Contacts
Public ContactChen Qihong
Yangzhou Jiangdu People's Hospital
Outcome results
None listed