Clinical study for pelvic floor neuromuscular electrical stimulation in the treatment of refractory thin endometrium

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053480

Enrollment

Unknown

Registered

2021-11-22

Start date

2021-11-22

Completion date

Unknown

Last updated

2022-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refractory thin endometrium

Interventions

Experimental group 1:NMES treatment

Experimental group 2:NMES treatment combined with estrogen therapy

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. After high-dose estrogen stimulation (Proganol 5mg tid + Fenmoton 1-2 pvqd) for 3m, endometrial thickness < 8mm; 2. Aged 25-40 years(before the 40th birthday); 3. BMI 18-25; 4. No other hormone drugs have been used within the past 3m; 5. No history of uterine cavity operation in the past 3m; 6. Voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Associated with endometrial organic diseases such as endometrial polyps, submucosal fibroids, Asherman's syndrome; 2. Abnormal liver and kidney function; 3. Severe EM, AM; 4. Gynecological malignant tumors, abnormal endometrial hyperplasia, endometrial cancer; 5. Genital deformities; 6. Thromboembolic disease; 7. Estrogen-dependent tumors, breast tumors, etc.; 8. History of TB; 9. Vaginitis; 10. Acute phase of various infectious diseases; 11. HT, DM, uncontrolled abnormal thyroid function; 12. Mental function and cognitive dysfunction, unable to cooperate with or tolerate treatment; 13. Vaginal wall prolapse; 14. Perianal skin rupture; 15. Rectal or vaginal bleeding; 16. Absolute contraindications to pelvic neuromuscular electrical stimulation, such as complete pelvic floor denervation (unresponsiveness), dementia, pacemaker, unstable or severe arrhythmias, unstable seizures, pelvic pain, and hemorrhoid pain.

Design outcomes

Primary

Measure	Time frame
endometrial thickness;	—

Secondary

Measure	Time frame
Hemodynamic parameters of the subendometrial blood flow;clinical pregnant rate;	—

Countries

China

Contacts

Public ContactWang Hanbi

Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences

zhw2005@aliyun.com+86 13651040365

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026