Survey of intravenous s-ketamine before one-lung ventilation in thoracoscopic surgery: influence on arterial oxygenation and postoperative pain

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053464

Enrollment

Unknown

Registered

2021-11-22

Start date

2021-11-22

Completion date

Unknown

Last updated

2022-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia management of lung cancer surgery

Interventions

S-ketamine group:s-ketamine (0.5mg/kg ) combined propofol

Placebo group:Patients received 0.9% saline placebo

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Subjects who elect to undergo video-assisted thoracoscopic radical surgery for lung cancer; 2. ASA grade I-II, aged between 50-70 years, FEV1/FVC% > 0.8, BMI < 28.

Exclusion criteria

Exclusion criteria: Previous history of severe allergy; Organic or mental illness; Serious alcohol or drug abuse.

Design outcomes

Primary

Measure	Time frame
Oxygenation index;Pulmonary shunt fraction (Qs/Qt);Contents of ET-1 and TXB2 in serum;	—

Secondary

Measure	Time frame
Postoperative pain score;cumulative consumption of hydromorphone;postoperative complications (nausea, vomiting and mental disorders);	—

Countries

China

Contacts

Public ContactZhou Yanfeng

The First Affiliated Hospital, Zhejiang University School of Medicine

zhouyf11@zju.edu.dcn+86 13858027837

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026