thyroidectomy
Conditions
Interventions
experimental group:Patients in the ketamine group will receive a bolus of 0.5 mg/kg S-ketamine in saline, followed by continuous infusion of 4 µg/kg/min S-ketamine in saline until 30 min prior to the
Placebo group:0.9% normal saline
Sponsors
Department of Anesthesiology and Perioperative Medicine, Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Selected patients with thyroid excision; 2. Age is not limited, ASA I-II level; 3. After fully explaining the contents of the clinical trial, voluntarily join and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe pulmonary hypertension, arrhythmia or cardiac insufficiency; 2. Patients with liver and kidney dysfunction; 3. Patients with increased intracranial pressure or intraocular pressure; 4. Patients who have recently taken analgesic and sedative drugs; 5. Patients with chronic pain in the past; 6. Mental disorders or alcohol and drug abusers; 7. Patients who are allergic to the drugs used in the study; 8. Patients who are pregnant or breastfeeding; 9. Patients who refuse to use postoperative analgesia; 10. Patients who have participated in other treatments in the last 6 months (when consent is obtained); 11. Patients who are judged to lack the ability to consent; 12. Others, patients who are judged as inappropriate by the clinically responsible doctor or the clinically-in-charge doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of sufentanil during Operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of analgesic medication after surgery;The amount of propofol during surgery;The amount of remifentanil during surgery;The amount of nonsteroidal anti-inflammatory drugs during surgery;Blood pressure, heart rate, BIS values at various points in the operation;The amount of vascular active drugs during surgery;Postoperative 0.5, 2, 4, 6, 12, 24h rest, movement NRS score;Sleep score at night after surgery;Postoperative time out of bed days in hospital;NRS scores of pain at 3 and 6 months postoperatively;Anesthesia time, surgery time, recovery time;Postoperative 30min RASS sedative score;Postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactWu Yun
Department of Anesthesiology and Perioperative Medicine, Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed