Brainstem hemorrhage
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosed patients with primary PPH: The diagnostic criteria included a clear history of hypertension, head CT indicated that the hematoma was located in the pontine brain, which could extend to the midbrain or medulla oblongata, and the hematoma could break into the third or fourth ventricle, which could be accompanied by obstructive hydrocephalus; 2. The amount of hematoma in brain stem parenchyma >=5ml was calculated by head CT (intraventricular hemorrhage was not included in the amount of bleeding); 3. Preoperative Glasgow coma score <8; 4. Time from onset to admission <=48 hours; 5. 18-75 years old.
Exclusion criteria
Exclusion criteria: 1. Cerebrovascular diseases include intracranial aneurysms, arteriovenous malformations, and cavernous vascular malformations; 2. Brainstem hemorrhage caused by tumor stroke; 3. Those with a history of coagulation dysfunction or anticoagulant drugs that cannot be corrected in the short term; 4. Combined with advanced brain herniation (bilateral mydriasis is fixed, no spontaneous breathing, blood pressure cannot be maintained); 5. Patients with liver and kidney failure or combined with systemic malignant tumors, and the expected survival period is less than 1 year; 6. History of mental disorder or neurological dysfunction in the past; 7. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rebleeding rate;mortality rate and intracranial infection rate;Modified Rankin scoring Scale;National Institutes of Health Stroke Scale;Glasgow Outcome Scale;Quality of Life (ED-5Q score);Quality of Life Self-rating scale; | — |
Countries
China
Contacts
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)