Post-Stroke Hemiplegia
Conditions
Interventions
Control group:Traditional hotspot target rTMS therapy
Intervention group:individualized rTMS therapy based on fMRI motor task activation points
Normal subjects:none
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Aged 20-75 years; 2. Stroke confirmed by imaging, the stroke focus is subcortical infarction located in the non-lateral motor area, and the type is hemiplegia with unilateral hemisphere injury; 3. The onset of the first stroke, with a course of more than 6 weeks 4. Brunnstrom classification (Brunnstrom, 1966) <= IV stage; 5. Agree to carry out rTMS treatment on the basis of conventional treatment, pass TMS safety screening, have no previous epilepsy and other neuropsychiatric diseases, and no other motor system diseases; 6. No contraindications for MRI scanning, no history of head trauma and severe heart disease; 7. Unconscious disturbance; 8. Can cooperate with the main test to complete the scale evaluation, MRI scan and TMS treatment; 9. Motor evoked potentials can be obtained in the contralateral hemisphere; 10. Able to complete hands-on tasks and obtain activation points in the lateral motor area of the unaffected hemisphere, and obtain the strongest functional connection between the lateral motor area of the affected hemisphere and the activation point of the unaffected hemisphere; 11. The head movement amplitude of all fMRI images is less than 2mm in translation and less than 2 degree in rotation; 12. Patients who voluntarily agree to join this study and sign the "informed consent form".
Exclusion criteria
Exclusion criteria: 1. Those who cannot tolerate the adverse reactions of transcranial magnetic stimulation, such as patients with metal implants in the body, VP shunts in the brain, arrhythmia, and a history of panic attacks; 2. Those with a pacemaker installed in the body; 3. Those who cannot cooperate; 4. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment-Upper Extremities, FMA-UE;MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Action Research Arm Test, ARAT;National Institute of Health Stroke scale, NIHSS;Barthel Index, BI;Study of Validity of Motor Status Scale;resting motor threshold;motor cortex excitability; | — |
Countries
China
Contacts
Public ContactWu Yi
Department of Rehabilitation, Huashan Hospital, Fudan University
Outcome results
None listed