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Increased DKK2 levels predict poor outcomes for acute ischemic stroke patients with large vessle occlusion

Correlation between incerased DKK2 levels and brain ischemia-reperfusion injury in stroke patients

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100053426
Enrollment
Unknown
Registered
2021-11-20
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke

Interventions

case series:Nil

Sponsors

Dongguan Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 80 years, gender is not limited; 2. Clinically diagnosed as acute ischemic stroke; 3. Baseline NIHSS score >= 6 points, and = 2b); 6. The subjects or their legal representatives agree to the treatment and sign the project informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with posterior circulation infarction; 2. mRS >= 2 points before the onset; 3. Patients who intend to use or have been treated with anticoagulant drugs; 4. Existing or enrolled patients with active organ hemorrhage within 6 months, including cerebral hemorrhage, subarachnoid hemorrhage, gastrointestinal hemorrhage, fundus hemorrhage, etc.; 5. There are other intracranial lesions, such as cerebral vascular malformations, cerebral venous lesions, tumors and other diseases involving the brain; 6. Severe organ dysfunction or failure; 7. Those with severe blood system disease or severe coagulation abnormality; 8. Those with a history of severe trauma or major surgical operations within 6 months before enrollment; 9. Pregnant or breastfeeding women; 10. Patients with life expectancy less than 3 months or patients who cannot complete the study for other reasons; 11. Other conditions deemed inappropriate by the investigator.

Design outcomes

Primary

MeasureTime frame
DKK2 and inflammatory factors;

Countries

China

Contacts

Public ContactShi Zhu

Dongguan Hospital of Southern Medical University

shizhu@smu.edu.cn+8613669825459

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026