Osteoarthritis of the knee
Conditions
Interventions
Group A:Preemptive analgesia was started 48 hours before surgery, and celecoxib was given orally 200mg every 12 hours, the last one hour before surgery
Group B:Preemptive analgesia was started 24 hours before surgery, and celecoxib was given orally 200mg every 12 hours, the last one hour before surgery.
Group C:Preemptive analgesia was started 1 hour before surgery, and celecoxib 400mg was given orally
Sponsors
Department of Orthopaedics Surgery, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who need unilateral primary TKA surgery due to severe knee osteoarthritis; 2. Aged 40~80 years; 3. The preoperative American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) was grade I-III.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the drugs used in this study; 2. There is moderate or higher knee joint deformity (varus and flexion) and joint stiffness; 3. Those who drink heavily or take opioids for a long time; 4. Language barriers and those who cannot complete the numerical rating scales (NRS) of pain; 5. Patients with neuropathy on the side of the operation; 6. Mental patients; 7. Those with previous peptic ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative dosage of remedial morphine hydrochloride; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;Range of knee motion;Daily walking distance;Incidence of postoperative complications;Time to first straight leg raise;The duration of hospital stay; | — |
Countries
China
Contacts
Public ContactKang Pengde
West China Hospital, Sichuan University
Outcome results
None listed