The effect of grononium bromide mediating postoperative cognitive dysfunction (POCD) via cholinergic anti-inflammatory pathway (CAP) on intestinal flora diversity in perioperative elderly patients

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053392

Enrollment

Unknown

Registered

2021-11-20

Start date

2021-11-15

Completion date

Unknown

Last updated

2022-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Cognitive Dysfunction

Interventions

Group 1:General Anesthesia

Group 2:Low-dose gronobium

Group 3:Medium-dose gronobium

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Elderly patients undergoing elective laparoscopic hernia repair under general anesthesia; 2. Aged >= 60 years.

Exclusion criteria

Exclusion criteria: 1. Patients with pyloric obstruction, glaucoma or prostatic hypertrophy; 2. MMSE score < 23, education < 7 years; 3. Suffering from central nervous system and mental diseases, including senile dementia, Alzheimer's disease, etc.; 4. Taking sedatives, antidepressants, alcoholism; 5. Those with severe visual or hearing impairment or unable to communicate with visitors for other reasons.

Design outcomes

Primary

Measure	Time frame
Fecal flora species;interleukin-1ß;interleukin-6;Tumor necrosis factor-a;5-Hydroxytryptamine;	—

Secondary

Measure	Time frame
Brain-derived neurotrophic factor;	—

Countries

China

Contacts

Public ContactZhang Li

Wuhan First Hospital

bzl6000@163.com+86 13971653949

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026