cholesterol gallstones
Conditions
Interventions
Experimental group1:15-18mg/(kg.d)ursodeoxycholic acid
Experimental group2:8-11mg/(kg.d) ursodeoxycholic acid
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Have signed the informed consent; 2. Aged 18 to 75 years, weight >= 45KG and <= 90KG, gender is not limited; 3. B-ultrasound diagnosis of gallbladder stones (including sediment-like stones), the largest diameter of gallbladder stones is less than or equal to 10mm, X-ray transparent (full light transmission).
Exclusion criteria
Exclusion criteria: 1. Suffered from acute cholecystitis, acute cholangitis, common bile duct stones, bile duct obstruction, acute pancreatitis within three months; 2. Gallbladder atrophy; 3. Gallbladder stones are opaque to X-ray, gallbladder-filled stones; 4. Frequent biliary colic, severe biliary colic, more than 3 times/week; 5. AST or ALT exceeds 2 times the upper limit of normal; 6. Combining other serious diseases affects the test compliance or efficacy evaluation; 7. Pregnant or planning pregnancy, lactating women; 8. Diagnosed or suspected malignant tumor in the past 5 years; 9. Taking other stone-dissolving drugs within 6 months before enrollment; 10. Those who are allergic to bile acids or any component of the study drug; 11. Those who have participated in other drug trials within 3 months; 12. The researcher believes that it is not suitable for the participant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete dissolution rate of gallbladder stones; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effectiveness of treatment;Biliary Abdominal Pain Score;Indigestion Symptom Score; | — |
Countries
China
Contacts
Public ContactXie Weifen
Shanghai Changzheng Hospital
Outcome results
None listed