infantile spasms
Conditions
Interventions
Experimental group1:After the end of the ACTH treatment for the first 2 weeks, change to oral prednisone 2 mg/kg.d for 2 weeks
Experimental group2:The ACTH dose was increased to 3 IU/kg.d and continued for 2 weeks
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
No minimum to 5 Years
Inclusion criteria
Inclusion criteria: 1. It is more common in infancy; 2. Typical characteristic clinical manifestations: nodding and hugging spasm, peak EEG arrhythmia with mental and motor development retardation; 3. The selected subjects are all new cases and have not been treated with immune preparations or various antiepileptic drugs.
Exclusion criteria
Exclusion criteria: 1. There is a known genetic disease; 2. There are major organ diseases, such as tachyarrhythmia, heart/lung/liver/kidney and other organ damage; 3. The guardian's lack of cooperation, including failure to cooperate with the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG changes before and after medication ;Spastic seizure remission rate and recurrence rate ;Lymphocyte subsets; | — |
Countries
China
Contacts
Public ContactLi Dongfang
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Outcome results
None listed