Parotid salivary fistula
Conditions
Interventions
Experimental group:Low dose bleomycin (7.5 mg) combined with OK-432 local injection can expose parotid acinar wound during operation
control group:Nil
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patient aged 18 to 75 years on the day of signing the informed consent form ; 2. Diagnosed as benign parotid tumor, and tumor resection and partial parotid gland resection are required; 3. The vital signs are stable, and the routine examination shows that the operation can be tolerated; 4. The patient has a good mental state, can follow the doctor's advice, and have regular follow-up visits; 5. Understand and be willing to participate in this clinical trial and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Existing underlying diseases will affect wound healing (such as autoimmune diseases); 2. Patients diagnosed with malignancy of the parotid gland, who need to undergo total parotidectomy and neck lymph node dissection at the same time, and require postoperative radiotherapy and chemotherapy; 3. The patient is a pregnant woman, a lactating woman during the screening period, or a woman who plans to become pregnant within six months after the end of the study; 4. Uncontrollable hyperglycemia (such as HbA1c > 12.0%); 5. Those with severe uncontrolled disease or acute systemic infection and those with other serious heart, lung, encephalopathy and other serious organ diseases; 6. Patients with psychiatric diseases; 7. Those who are considered inappropriate by the researchers to be included; 8. The patient participated in this study at any time in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parotid salivary fistula;Incidence of complications; | — |
Countries
China
Contacts
Public ContactZhou Bin
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Outcome results
None listed