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Exploring the mechanism of acupuncture in patients with impaired consciousness based on fNRIS technology

Clinical evaluation and mechanism study of therapeutic effect difference in patients with awakening disorder induced by acupuncture based on multi-modal imaging feature recognition

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053355
Enrollment
Unknown
Registered
2021-11-20
Start date
2021-11-20
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disturbance of consciousness

Interventions

Experimental group1:acupuncture

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet the above-mentioned diagnostic criteria for chronic disturbance of consciousness, including Chronic Coma, VS/UWS, and MCS stages; 2. Sudden disturbance of consciousness with clear etiology; 3. Right-handed; 4. Aged 18 to 75 years; 5. The vital signs are stable, and they have not participated in other clinical investigators; 6. Obtain the informed consent of the patient's legal representative.

Exclusion criteria

Exclusion criteria: 1. Complicated with intracranial tumor, intracranial infection episode or brain death; 2. Those who have a history of mental illness or drug or long-term alcohol addiction before brain injury; 3. Those who have a history of nervous system related diseases (neurodegeneration, stroke, etc.); 4. Patients with unstable condition and serious complications of respiratory and circulatory system have not been effectively controlled; 5. Patients with severe endocrine and metabolic diseases and other space-occupying diseases that significantly affect the research results; 6. Those who are in the acute phase after the onset of the disease, and the duration of the disorder of consciousness is less than 1 month; 7. Patients with status epilepticus; 8. Pregnancy, combined with multiple trauma, limb fracture or large area of skin defect; 9. Those with contraindications to fNIRS collection.

Design outcomes

Primary

MeasureTime frame
fNIRS data;

Secondary

MeasureTime frame
The Coma Recovery Scale–Revised;Glasgow Coma Scale;

Countries

China

Contacts

Public ContactHe Jing

West China Hospital of Sichuan University

rliuyiwei@qq.com+86 189 8060 1616

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026