disturbance of consciousness
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Meet the above-mentioned diagnostic criteria for chronic disturbance of consciousness, including Chronic Coma, VS/UWS, and MCS stages; 2. Sudden disturbance of consciousness with clear etiology; 3. Right-handed; 4. Aged 18 to 75 years; 5. The vital signs are stable, and they have not participated in other clinical investigators; 6. Obtain the informed consent of the patient's legal representative.
Exclusion criteria
Exclusion criteria: 1. Complicated with intracranial tumor, intracranial infection episode or brain death; 2. Those who have a history of mental illness or drug or long-term alcohol addiction before brain injury; 3. Those who have a history of nervous system related diseases (neurodegeneration, stroke, etc.); 4. Patients with unstable condition and serious complications of respiratory and circulatory system have not been effectively controlled; 5. Patients with severe endocrine and metabolic diseases and other space-occupying diseases that significantly affect the research results; 6. Those who are in the acute phase after the onset of the disease, and the duration of the disorder of consciousness is less than 1 month; 7. Patients with status epilepticus; 8. Pregnancy, combined with multiple trauma, limb fracture or large area of skin defect; 9. Those with contraindications to fNIRS collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fNIRS data; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Coma Recovery Scale–Revised;Glasgow Coma Scale; | — |
Countries
China
Contacts
West China Hospital of Sichuan University