Vascular stenosis of the internal carotid artery system
Conditions
Interventions
Experimental group:Basic treatment + intravenous Urinary Kallidinogenase 0.15PNA/d
Control group:Basic treatment
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Symptomatic patients, who have had nondisabling ischemic stroke or TIA within 6 months, and ipsilateral internal carotid artery diameter stenosis of more than 50% by noninvasive imaging or angiography; asymptomatic patients, by Non-invasive imaging or angiography found that the diameter of the ipsilateral internal carotid artery was narrowed by more than 70%; 2. Enrollment aged 18 to 80 years; 3. The consciousness is clear, and can cooperate with it to complete the evaluation of cognitive function; 4. Tolerable to surgery; 5. Before the start of the trial, the patients and their legal representatives voluntarily signed an informed consent form approved by the ethics committee.
Exclusion criteria
Exclusion criteria: 1. Severe neurological disorder has caused severe disability; 2. Those who have experienced massive cerebral infarction in the acute phase of cerebral hemorrhage and other hemorrhagic diseases or within 4 weeks; 3. Severe disturbance of consciousness: GCS score <= 8; 4. Those who have used ACEI drugs before administration of uracrine for injection and have not exceeded 5 half-lives (according to the specific drug instructions) and need to receive ACEI drugs during this study; 5. Severe heart, liver, kidney dysfunction, coagulation dysfunction or those who cannot tolerate surgery; 6. Diagnosed or suffered from any malignancy (except basal cell carcinoma) within 5 years prior to the start of the study; 7. Patients who are pregnant, breastfeeding or have the possibility of pregnancy and those who plan to become pregnant; 8. Those who are allergic to or intolerable to uricrine for injection in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral autoregulation;cerebral blood perfusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| neurological function deficits assessment;cognitive function assessment;inflammatory factors; | — |
Countries
China
Contacts
Public ContactFan Yuhua
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed