Skip to content

Application mechanism of Hebbian model paired stimulation to accurately regulate neural circuits to improve memory function in patients with amnestic mild cognitive impairment

Application mechanism of Hebbian model paired stimulation to accurately regulate neural circuits to improve memory function in patients with amnestic mild cognitive impairment

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053315
Enrollment
Unknown
Registered
2021-11-18
Start date
2021-11-06
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment

Interventions

Group 1:rTMS(repetitive transcranial magnetic stimulation)
Control group:No

Sponsors

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: aMCI patients: 1. Meet the diagnostic criteria of mild cognitive impairment; 2. Aged 50-80 years, unlimited gender, right-handed; 3. The complaint was memory loss with objective evidence (neuropsychological scale evaluation); 4. Years of education >= 6 years; 5. Those who understand and agree to participate in this study signed the informed consent form. Healthy subjects: 1. No chief complaint of cognitive impairment; 2. Aged 50-80 years, unlimited gender, right-handed; 3. No cognitive impairment (assessed by neuropsychological scale); 4. Years of education >= 6 years; 5. Those who understand and agree to participate in this study signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Complicated with tumor, severe heart, liver, kidney, blood system diseases or infectious diseases; 2. Previous neurological diseases such as cerebrovascular disease, Parkinson's syndrome and dementia caused by various reasons; 3. Previous mental diseases such as anxiety, depression and schizophrenia; 4. Severe audiovisual impairment; 5. There are magnetic resonance contraindications (such as a cardiac pacemaker, a cardiac stent, artificial heart valve, fixed plate after fracture surgery, etc.).

Design outcomes

Primary

MeasureTime frame
Neuropsychological test;

Secondary

MeasureTime frame
Magnetic Resonance Imaging;Neuroelectrophysiological indexes;Emotional and daily living ability test;TCM Syndrome Scale;

Countries

China

Contacts

Public ContactHua Xuyun

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

huaxuyun@shutcm.edu.cn+86 13564020161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026