Severe pneumonia
Conditions
Interventions
FMT group:Fecal-microbiota transplantation (FMT)
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Sign a written informed consent; 2. Female subjects must meet the following conditions to participate in the study: no potential fertility (that is, physiologically incapable of pregnancy, including women who have been menopausal for 2 years) or no pregnancy plan; 3. Severe pneumonia was diagnosed in the past month: based on the definition of the guidelines for the diagnosis and treatment of adult community-acquired pneumonia developed by the Respiratory Branch of Chinese Medical Association in 2016, the characteristics are as follows: (1) Main criteria: invasive mechanical ventilation; vasoactive drugs are still needed after active humoral resuscitation in septic shock; (2) Secondary criteria: respiratory rate > 30 beats/min; PaO2/FiO2 = 7 mmol/min; systolic blood pressure = 12 mmHg or at least 4 times a day is not lower than 12 mmHg); (3) Abdominal compartment syndrome (ACS): intra-abdominal pressure >= 20 mmHg and new organ dysfunction occurred at least twice in 6 hours; (4) Gastric retention: a single gastric juice withdrawal exceeding 200 ml is defined as massive gastric retention; (5) Diarrhea: more than three times a day dilute stool, and the amount is greater than 200~250 g/d (or more than 250 ml/d); (6) Vomiting fluid, stomach contents or feces and other samples occult blood test positive; (7) Lower gastrointestinal paralysis (paralytic intestinal obstruction): finger intestinal peristalsis function is impaired, resulting in feces can not be excreted from the body. Clinical symptoms include at least 3 days of anal cessation of defecation, the presence or disappearance of bowel sounds, and the need to rule out mechanical intestinal obstruction; 6. The subjects are willing and able to complete the follow-up according to the plan; 7. The subjects can cooperate to complete the relevant inspection items; 8. Compliance: subjects must be willing to return to hospital for follow-up according to the plan and complete all visit assessments.
Exclusion criteria
Exclusion criteria: 1. Critically ill patients with early resuscitation, hemodynamic instability and severe water-electrolyte acid-base imbalance; 2. Digestive system: (1) Patients with known gastrointestinal organic diseases; (2) Double infection with intestinal tract, such as Clostridium labile infection, Enterohemorrhagic Escherichia coli, Salmonella, Shigella, Campylobacter, Yersinia pestis and Cytomegalovirus, etc.; (3) Various acute infections, tumors, severe arrhythmias, mental system diseases, drug or alcohol addiction; (4) Massive gastrointestinal bleeding; (5) Contraindications to this study; (6) Other clinical researchers were being carried out at the time of joining the group or within 3 months before joining the group; 3. Severe primary diseases of important organs or systems such as heart, liver, kidney and hematopoietic system were complicated; 4. Patients with waist and back, chest and abdomen injury or after operation; 5. People with mental abnormality and cognitive impairment; 6. There are doubts about the validity of informed consent: subjects with a history of mental illness, mental retardation, poor motivation, drug abuse (including drugs and alcohol) or other diseases that restrict the effectiveness of informed consent in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora;Plasma metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation indicators;Intestinal barrier function; | — |
Countries
China
Contacts
Public ContactZheng Zeguang
Guangzhou Medical University
Outcome results
None listed