Pain
Conditions
Interventions
ESI(epidural steroid injection) group :Epidural injection of compound betamethasone
EPRP(epidural platelet rich plasma injection) group:Epidural injection of platelet rich plasma
Sponsors
Hong Kong University-Shen Zhen Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 60 years; 2. NRS pain score > 3 over the week; 3. Onset of herpes zoster within 1 month; 4. Able to provide informed consent; 5. Thoracolumbar herpes zoster.
Exclusion criteria
Exclusion criteria: 1. Patients requiring surgical intervention; 2. Bilateral involvement of herpes zoster; 3. Coagulopathy (platelet count less than 100,000/mL, international normalized ratio [INR] over 1.5); 4. Using anticoagulant and/or antiplatelet medication; 5. Received epidural steroid injection within the past 1 year; 6. Systemic infection; 7. Allergic to contrast dye, steroids, PRP, local anaesthetic; 8. Pregnancy; 9. Physically unable to tolerate epidural injection; 10. Uncontrolled psychiatric disorder; 11. Active or a history of substance use disorder (including alcohol opioid); 12. Known serious disorder of immunity (e.g. AIDS); 13. Those receiving systemic steroid therapy; 14. Heavy skin eruption (no suitable skin area for needle injection); 15. Those who received spinal surgery or had severe spinal malformation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;Percentage of pain relieve; | — |
Secondary
| Measure | Time frame |
|---|---|
| SF-36(short form 36 questionnaire);Psychological assessment; | — |
Countries
China
Contacts
Public ContactLi Xuanying
Hong Kong University-Shen Zhen Hospital
Outcome results
None listed