Helicobacter pylori infection
Conditions
Interventions
high-dose dual therapy group:high-dose dual therapy
bismuth-containing quadruple therapy :bismuth-containing quadruple therapy group
healthy group:none
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. H. pylori infection; 3. Informed and agreed to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Presence of severe diseases or clinical conditions; 2. H. pylori eradication treatment; 3. Have used antibiotics and probiotics in the past one year; 4. Have taken PPI, NSAIDs, mucosal protectants, immunosuppressants or hormones in the last 3 months; 5. Allergy to penicillin or other medications used in this study; 6. Female patients who are pregnant or breastfeeding; 7. Patients who are not suitable for enrollment after assessment by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal microecology;Change of gastric mucosa histology; | — |
Secondary
| Measure | Time frame |
|---|---|
| Digestive tract symptoms before and after treatment;The eradication rate of H. pylori;Adverse events;Bristol stool score; | — |
Countries
China
Contacts
Public ContactLi Peiyuan
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wenchang People's Hospital
Outcome results
None listed