General anesthesia induction and maintenance of elective short-term surgery in adults
Conditions
Interventions
Group A:During the induction period, remazolam 0.1 mg/kg was administered intravenously for 60 seconds
Group B:During the induction period, remazolam 0.15 mg/kg was administered intravenously for 60 seconds
Group C:During the induction period, remazolam 0.2 mg/kg was administered intravenously for 60 seconds
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-III; 2. Aged 18-65 years; 3. Gender is not limited; 4. Planned elective support laryngoscope surgery (glottic polypectomy under support laryngoscope, epiglottic cyst excision under support laryngoscope, benign laryngeal under support laryngoscope Lesion resection), endoscopic septum plasty, endoscopic tympanoplasty, endoscopic middle ear tube insertion, nasopharyngoplasty, head and neck benign mass resection, general anesthesia intubation patients; 5. Operation time <= 90 min.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Abnormal renal function (blood urea nitrogen >= 1.5 x ULN, serum creatinine greater than the upper limit of normal); 3. Abnormal liver function; 4. Hypovolemia, shock or coma; 5. Suffering from mental system diseases and long-term use of psychotropic drugs; 6. Cognitive dysfunction; 7. Those who are allergic to or have contraindications to the components of benzodiazepines; 8. Pregnant or lactating female patients; 9. Have a history of drug dependence; 10. Use of other sedative drugs in the past week; 11. Participated in drug clinical trials as subjects within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension in the induction and maintenance phases;Sedation success rate of remazolam tosylate in the induction and maintenance phases; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ttime for BIS(bispectral index) to drop to 40-60;Frequency and duration ratio of intraoperative hypotension;Intraoperative awareness rate;Ratio of occurrences and duration of BIS > 60 and BIS < 40;Time from drug withdrawal to recovery of consciousness (waking time);Time from start of drug injection to complete disappearance of consciousness;Time for MOAA(modified observer’s assessment of alert)/S score to 0; | — |
Countries
China
Contacts
Public ContactGong Xingrui
Xiangyang Central Hospital
Outcome results
None listed