Atopic dermatitis
Conditions
Interventions
Experimental group 1:Wet-wrap treatment with fluticasone propionate cream 0.05%
Experimental group 2:Wet-wrap treatment with hydrocortisone butyrate 0.1% cream
Experimental group 3:0.05% Fluticasone propionate cream for external application
Sponsors
Dermatology Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
4 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. Children aged 4-14 years, in hospital and outpatient departments, no gender limitation; 2. Clinical diagnosis meets AD (Hanifin and Rajka diagnostic criteria); 3. Lesions affected area >= 10% BSA; 4. Moderate AD: SCORAD 25-50, severe AD: SCORAD > 50; 5. The patients and their guardians voluntarily participate in the study, sign informed consent, and agree to timely visit the researcher during the study as required.
Exclusion criteria
Exclusion criteria: 1. Patients with mild AD: SCORAD0-24(BSA < 10%); 2. Known allergic history to test drugs or drugs with similar chemical structure; 3. Other diseases that cause abnormal levels of plasma cortisol and ACTH; 4. Patients with other skin diseases (such as psoriasis, etc.) or atopic dermatitis in the skin area considered by researchers to affect the determination of skin lesions; 5. Patients who have systematically used steroids or immunosuppressants in the past 4 weeks; 6. Active systemic or local infections of clinical significance, including but not limited to secondary infections of atopic dermatitis, local bacterial, viral and fungal infections, etc.; 7. Patients with obviously low immune system function and chronic diseases such as diabetes; 8. There are obvious skin atrophy and hair folliculitis in the lesions, which may affect the judgment of drug safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eczema area and severity index;Plasma cortisol and adrenocorticotropic hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin pH test;Transepidermal water loss;The invesitigator's global assessment;Itch number rating scale;Pediatric Dermatology Quality of Life Index;Blood routine examination;Total IgE; | — |
Countries
China
Contacts
Public ContactLiang Yunsheng
Dermatology Hospital of Southern Medical University
Outcome results
None listed