Study on blood concentration monitoring and dosing regimen optimization of commonly used antibiotics in patients with continuous renal replacement therapy (CRRT)

Pharmacokinetics and rational dosing regimen of commonly used antibiotics in continuous renal replacement therapy (CRRT) patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100053246

Enrollment

Unknown

Registered

2021-11-17

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Meropenem Group :Nil

Imipenem Group :Nil

Piperacillin/tazobactam Group :Nil

Cefoperazone/sulbactam Group :Nil

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adults (aged >=18 years); 2. Admission to the ICU room for monitoring; 3. CRRT (CVVH, CVVHD or CVVHDF) and antibiotics should be given at the same time according to the judgment of the doctor.

Exclusion criteria

Exclusion criteria: 1. Those who have undergone major surgical operations within 4 weeks before the trial; 2. Those who are clearly allergic to the experimental antibiotics or their preparation components; 3. HIV patients, terminal cancer patients and pregnant women, etc.; 4. Those who are unable to complete the study due to other reasons or the researchers think should not be included.

Design outcomes

Primary

Measure	Time frame
Drug concentration in plasma and CRRT effluent;	—

Countries

China

Contacts

Public ContactZhang Qiang

The Third Xiangya Hospital, Central South University

37417217@qq.com+86 15116373706

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026