Postoperative Neurocognitive Dysfunction (PND)
Conditions
Interventions
Control group:None
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Elderly orthopedic surgery patients aged 65-85 years received total intravenous anesthesia.
Exclusion criteria
Exclusion criteria: 1. The patient refuses to accept the trial; 2. ASA>IV grade; 3. Unconsciousness, previous mental or psychological disorders; 4. Severe vision, hearing and language impairment, years of education < 9 years; 5. Previous use of sedatives or antidepressants, long-term alcohol and drug use, and recent history of antibiotic use; 6. Diabetes; 7. Cerebrovascular disease within 6 months including history of cerebral hemorrhage or cerebral embolism or coexisting neurological sequelae for more than 6 months; 8. Brain tumor; 9. Epilepsy, Parkinson's, cerebrovascular dementia; 10. Cardiovascular diseases such as myocardial infarction in June; 11. Tumor disease, acute trauma or inflammatory disease, etc.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Gut microbime;Short-chain fatty acids in blood;Gut barrier protein;Endotoxin;Systemic inflammatory factors;Serum mucin-1;Fibroblast growth factor 1/2;Endotoxin binding protein; | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative neurocognitive impairment; | — |
Countries
China
Contacts
Public ContactDuan Mei
Xuanwu Hospital of Capital Medical University
Outcome results
None listed