General anesthesia with remimazolam in obese patients
Conditions
Interventions
Remimazolam group:Induction by inject remimazolam
Propofol group :Induction by inject propofl
Sponsors
The Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.ASA grade I-III; 3.Body mass index (BMI) >= 28kg/m^2; 4.Participated in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with Mallampati grade IV who need conscious endotracheal intubation determined by the investigator; 2.Allergic or contraindicated to benzodiazepines, opioids, propofol, flumazenil, naloxone and other drugs and their components; 3.Severe cardiovascular, neuropsychiatric or cerebrovascular disease or severe liver or kidney disorder; 4.Alcoholism and long-term use of sleeping pills; 5.Pregnant or lactating women; 6.Other conditions deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of successful induction of anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in blood pressure, heart rate and blood oxygen;Changes in bispectral index of electroencephalogram;Percentage of subjects successfully induced anesthesia;Comparison of proportion and dosage of remedial sedatives in subjects during induction;vital signs; | — |
Countries
China
Contacts
Public ContactChang Huan
The Third Xiangya Hospital, Central South University
Outcome results
None listed