CSF1R microglial encephalopathy
Conditions
Interventions
Experimental group:Stem cells for research
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria of CSF1R microglial encephalopathy (appendix II); 2.Have a genetic diagnosis confirming the presence of a CSF1R gene mutation; 3.Aged 18 to 60 years, regardless of gender; 4.Duration of disease > 2 years; persistent exacerbation of symptoms and no contraindications to treatment; 5.Able to guarantee completion of the full research project of this study and able to cooperate with the physician in treatment and follow-up; 6.Have not received stem cell transplantation within the last 6 months; 7.Have not participated in any clinical trial studies within the last 3 months; 8.Consent to stem cell therapy and voluntarily sign an informed consent form; 9.Be treated with umbilical cord MSCs and sign the informed consent form in person or by a relative.
Exclusion criteria
Exclusion criteria: 1.Severe dyslexia, severe audio-visual impairment, etc., which prevents completion of cognitive function assessments; 2.Combined contraindications to magnetic resonance imaging, such as claustrophobia, pacemakers, metal implants, etc. 3.Combination of severe heart, lung, liver, kidney, malignancy, haematological disorders and other brain disorders with unstable vital signs; 4.Patients who have participated in other drug clinical trials or are participating in other clinical trials within 3 months prior to screening; 5.Patients who, in the opinion of the investigator, are not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| activities of daily living;motor function; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognition function;high signal volume in white matter;mental behavior;annual recurrence rate; | — |
Countries
China
Contacts
Public ContactXu Jun
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed