Repeated transcranial direct current stimulation in disorders of consciousness: a randomized, double-blind controlled trial study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053108

Enrollment

Unknown

Registered

2021-11-11

Start date

2018-08-01

Completion date

Unknown

Last updated

2022-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of consciousness

Interventions

shame stimulus group:Transcranial direct current sham stimulation

true stimulus group:Transcranial direct current true stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Clinical diagnosis of VS/UWS or MCS according to standardized clinical diagnostic criteria, and stable level of responsiveness as assessed by the JFK Coma Recovery Scale-Revised (CRS-R); 2. Traumatic, anoxic or vascular aetiology; 3. More than 1 months post injury; 4. Aged 18-80 years.

Exclusion criteria

Exclusion criteria: 1. Pre-existing severe neurological or systemic diseases; 2. Patients were studied free of sedative drugs and Na+ or Ca++ channel blockers (e.g., carbamazepine) or NMDA receptor antagonists (e.g., dextromethorphan) or intrathecal baclofen in order to avoid possible interaction with the effects of tDCS; 3. Patients with other electric/electromechanical devices and uncontrolled epilepsy.

Design outcomes

Primary

Measure	Time frame
JFK Coma Recovery Scale-Revised (CRS-R);	—

Countries

chinese

Contacts

Public ContactZhang Fang

The Second Hospital of Lanzhou University

zhangfanggslz@126.com+86 13919128267

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026